Memorial Sloan Kettering Cancer Center
MULTIPARAMETRIC MR IMAGING OF PROSTATE CANCER AT HIGH FIELD CLINICAL MR SCANNER
Amita Dave, PhD
Associate Professor (left)
Hedvig Hricak, MD, PhD
Professor and Chairman, Department of Radiology (right)
KEY ACCOMPLISHMENTS:
A novel approach to generating and analyzing multi-parametric MRI and molecular markers was successfully developed and implemented in phantoms and animal model of prostate cancer at 4.7T.
Brigham and Women’s Hospital, Harvard Medical School
ADVANCEMENT OF QUANTITATIVE T2 RELAXATION IMAGING AND HIGH SPATIAL RESOLUTION 3D IMAGING FOR IMPROVED TISSUE CHARACTERIZATION AND LOCALIZATION OF PROSTATE CANCER FOR IMAGE-GUIDED THERAPY
Robert Mulkern, PhD
Associate Professor of Radiology
KEY ACCOMPLISHMENTS:
Novel approach to T2-weighted prostate MRI at 3T was developed and tested in phantoms and finalized for the future clinical trial and implementation.
University of California, San Francisco
MRI PREDICTION OF DISEASE PROGRESSION IN PATIENTS DIAGNOSED WITH PROSTATE CANCER AND MANAGED WITH ACTIVE SURVEILLANCE
John Kurhanewicz, PhD
Professor of Radiology and Director, NMR Center
KEY ACCOMPLISHMENTS:
This retrospective study demonstrated that mpMRI improved selection of patients for AS. Indeed, it showed that patients with suspicious lesions on mpMRI had a four-fold increase in the risk of Grade upgrading at subsequent biopsies (than did patients without such lesions).
Brigham and Women’s Hospital, Harvard Medical School
MULTI-PARAMETRIC (MP) PROSTATE MR IMAGE ANALYSIS
Dr. Clare Tempany, MD
Professor and Ferenc Jolesz Chair of Radiology Research
KEY ACCOMPLISHMENTS:
This study developed and tested a robust approach to the measurement of prostate cancer volume, based on the 3D image analysis software developed by the world leading academic Surgical Planning Laboratory, which was made widely available due to its open architecture. This groundbreaking work is critical for prostate cancer clinical assessment, treatment planning and monitoring.
University of Chicago
EX-VIVO MRI MICROSCOPY OF PROSTATE CANCER AT 9.4T
Aytekin Oto, MD
Professor of Radiology and Head of Body MRI
KEY ACCOMPLISHMENTS:
This study developed a successful original approach for ex vivo MRI of prostate tissue samples and its correlation with pathology at very high field strength. This work had led to new approaches to novel in vivo MRI for the prostate expected to improve sensitivity and specificity for detection of high Gleason score (aggressive) lesions and to pathologic tissue analysis using high resolution 3D ex vivo MR images.
University of California, Los Angeles
MULTI-PARAMETRIC (MP) PROSTATE MRI FOR IMPROVING PATIENT SELECTION FOR BIOPSIES AND TREATMENT
Daniel Margolis, MD
Associate Professor of Radiology and Co-Director, Center for Prostate Imaging
KEY ACCOMPLISHMENTS:
The goal of this study is to demonstrate mpMRI is a feasible diagnostic tool for improved detection of aggressive prostate cancer and its differentiation from low risk and benign disease (in progress).
AdMeTech Foundation
CLINICAL TRIAL OF MPMRI AND PI-RADS FOR IMPROVED DETECTION OF AGGRESSIVE PROSTATE CANCER
Faina Shtern, MD
President and CEO of AdMeTech Foundation
KEY ACCOMPLISHMENTS:
The goal of this study is to generate conclusive, statistically powered scientific evidence on the clinical value of mpMRI in the improved risk stratification and elimination of unnecessary biopsies and treatment (in progress).